Glycolipid transfer protein domain

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August undefined, 2024

WebMar 23, 2015 · A protein encoded by glycolipid transfer protein-containing domain 1 (GLTPD1), a gene predicted to exist in the human genome only by computer annotation, has been shown to form a GLTP-fold that specifically transfers ceramide-1-phosphate (C1P) rather than glycolipids between membranes. Accordingly, the GLTPD1 protein has been … WebJan 23, 2007 · Glycolipid transfer protein. Gene. GLTP. Status. UniProtKB reviewed (Swiss-Prot) Organism. Homo sapiens (Human) Amino acids. 209. Protein existence. …

The orchestra of lipid-transfer proteins at the crossroads between ...

WebOct 8, 2007 · Lipid transfer by FAPP2 has not been studied previously, but it contains a domain that is also found in glycolipid transfer protein (GLTP), which transfers simple glycolipids in vitro (Brown and Mattjus, 2007).FAPP2 had been shown to contribute to an aspect of membrane traffic from the TGN to the plasma membrane (Godi et al., 2004), … GLTP; PLEKHA8; PLEKHA9; nightlight home study

CDD Conserved Protein Domain Family: GLTP - National Center for ...

WebJul 1, 2007 · containing a putative glycolipid transfer protein (GLTP) domain [106,107]. BLAST. alignments show the 194 amino acid, carboxy-terminus of FAPP2 to be 33% identical and 46%. Web多数据库分析肝细胞癌中gltpd2的表达及临床意义-来源：激光生物学报（第2024001期）-中国遗传学会.pdf,第 31 卷第 1 期激光生物学报 vol. 31 no. 1 2024 年 2 月 acta laser biology sinica feb. 2024 多数据库分析肝细胞癌中gltpd2 的表达及临床意义 1，3 2 1，3 1，3 1，3 1，3* 张湘豫，张艳群，卢梦云，胡溢洪 ... WebDec 14, 2024 · FAPP2 consists of an N-terminal pleckstrin homology domain that recognizes the Golgi marker phosphatidylinositol 4-phosphate, a central proline-rich region, and a glycolipid transfer protein (GLTP)–like domain in the C terminus. nightlight hidden spy camera

Lipid transfer proteins: the lipid commute via …

A lipid transfer protein that transfers lipid Journal of Cell …

WebJan 1, 2016 · By contrast, the secondary structure of the glycolipid transfer protein (GLTP) domain solely consists of helices [33] (Fig. 1). Download : Download high-res image (2MB) Download : Download full-size image; Fig. 2. Expression pattern of LTPs in human tissues. LTPs are generally expressed in virtually all tissues in human. The detailed tertiary structure of albumin was eagerly awaited both by protein … In this study, we have shown that a (glyco)sphingolipid binding domain … Another option for altering lipid raft compositions is to develop protein … This illustrates the drawback of looking at isolated domains from a multi-domain … The yeast transfer protein forms a complex with phosphatidylinositol or phosphatidyl … Proteins that specifically bind and transfer glycolipids between artificial … The oxidation of HDL 3 by Cu(II) and its effect on the ability of these particles to … The mammalian glycolipid transfer protein, GLTP, catalyzes the transfer in vitro of … The aggregative properties of gangliosides in diluted aqueous solutions are … Chromatofocusing reveals that glycolipid transfer protein activity co-elutes with … nremt emt basic recertificationWebAug 8, 2007 · FAPP2 has sequence similarity to glycolipid-transfer protein (GLTP) 4, 7, a protein able to mediate the intermembrane transfer of glycosphingolipids (GSLs) in vitro 8. GSLs are important ... nremt exam study tips

"WebOct 28, 2005 · Mammalian glycolipid transfer proteins (GLTPs) are potential regulators of cell processes mediated by GSLs and display a unique architecture among lipid binding/transfer proteins. The GLTP fold represents a novel membrane targeting/interaction domain among peripheral proteins. " - Glycolipid transfer protein domain

Glycolipid transfer protein domain

Glycosphingolipid synthesis requires FAPP2 transfer of

WebGlycolipid transfer protein (GLTP) is a soluble 24 kDa protein that selectively accelerates the intermembrane transfer of glycolipids in vitro. Little is known about the GLTP structure and dynamics. Here, we report the cloning of human GLTP and characterize the environment of the three tryptophans (Trps) of the protein using fluorescence … WebSep 6, 2007 · FAPP2 also possesses a glycolipid-transfer-protein homology domain. Here we show that human FAPP2 is a glucosylceramide-transfer protein that has a pivotal role in the synthesis of complex glycosphingolipids, key structural and signalling components of the plasma membrane. The requirement for FAPP2 makes the whole …

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WebNov 4, 2024 · glycolipid transfer protein 1 Primary source Araport:AT2G33470 Locus tag AT2G33470 Gene type protein coding ... EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Glycolipid transfer protein, GLTP (InterPro:IPR014830); BEST Arabidopsis thaliana protein match is: Glycolipid transfer protein (GLTP) family … WebGlycolipid transfer proteins (GLTPs) originally were identified as small (~24 kDa), soluble, amphitropic proteins that specifically accelerate the intermembrane transfer of glycolipids. GLTPs and related homologs now are known to adopt a unique, helically dominated, two-layer 'sandwich' architecture defined as the GLTP-fold that provides the ...

WebApr 1, 2024 · Glycolipid transfer activity by the isolated FAPP2-GLTPH domain became evident only after cloning of the bona fide full-length protein (519 residues). This protein included 12 residues missing from the C-terminus of an earlier FAPP2 clone, explained by a cloning-induced mutation artefact involving a premature TTA stop codon rather than the ... WebInterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.

WebGlycolipid transfer proteins (GLTPs) were first identified over three decades ago as ~24kDa, soluble, amphitropic proteins that specifically accelerate the intermembrane … WebGlycolipid transfer protein (GLTP) accelerates glycosphingolipid (GSL) intermembrane transfer via a unique lipid transfer/binding fold (GLTP-fold) that defines the GLTP superfamily and is the prototype for GLTP-like domains in larger proteins, i.e. phosphoinositol 4-phosphate adaptor protein-2 (FAPP2). Although GLTP-folds are …

WebPhosphoinositol 4-phosphate adaptor protein-2 (FAPP2) plays a key role in glycosphingolipid (GSL) production using its C-terminal domain to transport newly synthesized glucosylceramide away from the cytosol-facing glucosylceramide synthase in the cis-Golgi for further anabolic processing. Structural …

WebGlycolipid transfer protein is a cytosolic protein that catalyses the transfer of glycolipids between different intracellular membranes.[1][2] For faster navigation, this Iframe is … nightlight hillsboro moWebJun 1, 2007 · Glycolipid transfer proteins (GLTPs) are small (24 kDa), ... Human FAPP2 is a 507 amino acid protein, encoded by a gene on chromosome 7, containing a glycolipid transfer protein (GLTP) domain [106], [107]. BLAST alignments show the 194 amino acid, carboxy-terminus of FAPP2 to be 33% identical and 46% similar to GLTP (209 amino … nremt instructions to evaluatorsWebOct 18, 2024 · NPC1 is a large multidomain protein: its amino terminus comprises a cholesterol-specific lipid transfer domain, which is exposed to the lysosomal lumen 125 and delivers cholesterol to the ... nremt exam study guideWebBy searching databases for transcripts similar to glycolipid transfer protein (GLTP; 608949 ), Simanshu et al. (2013) identified GLTPD1, which they called CPTP. The … night light hm-49WebGlycolipid transfer protein (GLTP); GLTP is a cytosolic protein that catalyzes the intermembrane transfer of glycolipids. The actual alignment was detected with superfamily member pfam08718 : Pssm-ID: 430172 Cd Length: 140 Bit Score: 194.64 E-value: 5.00e-64 night light homebaseWebBy searching databases for transcripts similar to glycolipid transfer protein (GLTP; 608949 ), Simanshu et al. (2013) identified GLTPD1, which they called CPTP. The deduced protein contains 214 amino acids. PCR analysis detected variable CPTP expression in all 16 human tissues examined, with highest expression in placenta, kidney, pancreas, and ... night light holders glassWebSep 29, 2024 · pfam08718 (PSSM ID: 430172): Conserved Protein Domain Family GLTP, GLTP is a cytosolic protein that catalyzes the intermembrane transfer of glycolipids … night light® hinoki cypress