Laminin g domain

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August undefined, 2024

Tīmeklis2024. gada 13. apr. · Mature Laminin α4 is a subunit of Laminin 411, Laminin 421, and Laminin 423. Mature Laminin α4 is a 1792 amino acid (aa) residue protein that has a Laminin N-terminal domain, four Laminin EGF-like domains, the coiled-coil domain, and five C-terminal tandem Laminin G-like domains. The G-like domains contain …

An attempt to develop mouse model for anti-laminin γ1 …

Tīmeklis2000. gada 1. febr. · The C-terminus of the laminin alpha chain contains a tandem of five laminin G-like (LG) domains. We report the 2.0 A crystal structure of the … Tīmeklis1990. gada 1. febr. · cathepsin G was found to cleave laminin initially at two sites only (Fig. 2, arrows), thus making available a frag-ment Ci-4 (Fig. 1G) comprising the intact short arms, and a fragment C8-9 (Fig. iF) comprising the entire rodlike region of the long-arm and globular domains G1-G3. Laminin is unevenly glycosylated, average … nuc ff14

Neurexin IV, caspr and paranodin—novel members of the

Tīmeklisthe structure of the ligand-binding domain of neurexin 1beta: regulation of lns domain function by alternative splicing: 1d2s: crystal structure of the n-terminal laminin g-like … Tīmeklis2024. gada 13. nov. · Laminin G Domains of Protein S Bind and Inhibit Fixa. Blood (2024) 134 (Supplement_1): 3624. Background: Protein S (PS) is a vitamin K … TīmeklisLaminin 521 is a new anti-GBM disease pulmonary hemorrhage autoantibody target. Studies have shown that in anti-glomerular basement membrane disease, circulating antibodies can recognize Laminin 521 in addition to type IV collagen, indicating that Laminin 521 is Another major autoantigen against GBM [10], autoantibodies against … nucf20br

Laminin G-like domains: dystroglycan-specific lectins - PubMed

LAMA5 Gene - GeneCards LAMA5 Protein LAMA5 Antibody

Tīmeklis2024. gada 4. jūn. · Indeed, LAMA possesses five laminin-type G domain (LG) modules at the C-terminus, arranged in a tandem array, that are differentially processed under homeostatic conditions or during tissue repair ... Tīmeklis2024. gada 15. maijs · The first insights into the structure of laminin-111 were obtained by using rotary shadowing electron microscopy, which revealed four arms: a long arm (∼77 nm in length) terminating in a pronounced globule (the ‘G domain’ from which the LG domains derive their name), and three shorter arms (∼34 nm in length) … nim wan road northTīmeklisBackground We recently reported that the autoantibodies of anti-p200 pemphigoid sera react with laminin γ1 and renamed this entity as anti-laminin γ1 pemphigoid. However, it has not been clarified whether the anti-laminin γ1 autoantibodies, particularly those to the C-terminal integrin binding site, affect the dermoepidermal junction and cause … nuc firmware utility

"TīmeklisThe nomenclature of laminins is based on the composition of α, β, and γ chains, so that a laminin composed of α2, β1, and γ1 chains is described as laminin 211. … " - Laminin g domain

Laminin g domain

Biotinylated Anti-mouse Laminin a4 Antibody

TīmeklisThe C-terminal domain is composed of five laminin G (LG) domains, important for cell receptor binding to, predominantly, integrin-α7β1 and the dystroglycan protein complex (DGC; Timpl and Brown, 1996; Figure 1A). These linkages modulate communication between the basal lamina of the ECM and muscle cell cytoskeleton. They also … Tīmeklis2000. gada 1. aug. · Abstract. Laminin G domain-like (LG) modules of approximately 180–200 residues are found in a number of extracellular and receptor proteins and often are present in tandem arrays. LG modules are implicated in interactions with cellular receptors (integrins, α-dystroglycan), sulfated carbohydrates and other extracellular …

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TīmeklisThe sex hormone binding globulin (SHBG)-like region of protein S, consisting of two laminin G-like domains (LG1 and LG2), contains the binding site for C4b-binding … Tīmeklis2002. gada 26. nov. · The functional importance of the α4 laminin G domain is emphasized by our in vitro and in vivo studies. In the former, we have shown that antibodies against the same G 1 /G 2 domain fragment block branching morphogenesis of endothelial cells maintained on artificial basement membrane proteins .

TīmeklisThe N-terminus consists of a globular domain (LN), followed by six laminin EGF-like (LE) domains. These N-terminal domains are located in the basement membrane and may be involved in binding to collagen VII. The C-terminal half of laminin β3 participates in two coiled-coil domains that mediate trimerization with the α3 and γ2 chains in the ... Tīmeklis2024. gada 21. marts · EGFLAM (EGF Like, Fibronectin Type III And Laminin G Domains) is a Protein Coding gene. Diseases associated with EGFLAM include Adiaspiromycosis and Congenital Muscular Dystrophy-Dystroglycanopathy Type A5 . Gene Ontology (GO) annotations related to this gene include calcium ion binding and …

Tīmeklis2024. gada 8. marts · Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, … Tīmeklis2011. gada 3. marts · Crystallization of a laminin short-arm fragment. As LN domains cannot be produced in isolation (Ettner et al, 1998; Odenthal et al, 2004), we produced a series of laminin short-arm fragments containing the LN domain, followed by 2–4 LEa domains (supplementary Table S1 online).The best crystals we obtained were of an …

TīmeklisThe EGF-like domain is an evolutionary conserved protein domain, which derives its name from the epidermal growth factor where it was first described. It comprises about 30 to 40 amino-acid residues and has been found in a large number of mostly animal proteins. Most occurrences of the EGF-like domain are found in the extracellular …

TīmeklisDrawing: All Atoms Virtual Bond. Aligned Rows: up to 5 up to 10 All 21 rows. Download Cn3D. PubMed References. pfam00054 is a member of the superfamily cl22861. … nim without gcTīmeklis14107 Ensembl ENSG00000083857 ENSMUSG00000070047 UniProt Q14517 n/a RefSeq (mRNA) NM_005245 NM_001081286 NM_010179 RefSeq (protein) … nuc fan cleaningTīmeklisLaminins are the major cell-adhesive proteins in the basement membrane, consisting of three subunits termed α, β, and γ. The putative binding site for integrins has been mapped to the G domain of the α chain, although trimerization with β and γ chains is necessary for the G domain to exert its integrin binding activity. The mechanism … nim with a twistTīmeklisPikachurin, also known as AGRINL (AGRINL) and EGF-like, fibronectin type-III and laminin G-like domain-containing protein (EGFLAM), is a protein that in humans is … nim with 64-channel dspThe exact function of the Laminin G domains has remained elusive, and a variety of binding functions has been ascribed to different Laminin G modules. For example, the laminin alpha1 and alpha2 chains each have five C-terminal laminin G domains, where only domains LG4 and LG5 contain binding sites for … Skatīt vairāk Laminins are a family of glycoproteins of the extracellular matrix of all animals. They are major components of the basal lamina (one of the layers of the basement membrane), the protein network foundation for most cells and organs. … Skatīt vairāk In humans, fifteen laminin trimers have been identified. The laminins are combinations of different alpha-, beta-, and gamma-chains. • Five … Skatīt vairāk Dysfunctional structure of one particular laminin, laminin-211, is the cause of one form of congenital muscular dystrophy. Laminin-211 is … Skatīt vairāk Laminins contain several conserved protein domains. Laminin I and Laminin II Laminins are … Skatīt vairāk Laminins form independent networks and are associated with type IV collagen networks via entactin, fibronectin, and perlecan. … Skatīt vairāk Together with other major components of the ECM, such as collagens and fibronectin, laminins have been used to enhance mammalian cell culture, especially in the case of … Skatīt vairāk • Laminin domain I: all laminin alpha chains (LAMA1, LAMA2, LAMA3, LAMA4, LAMA5) • Laminin domain II: all laminin alpha chains (LAMA1, LAMA2, LAMA3, LAMA4, LAMA5) Skatīt vairāk nim\u0027s island trailerTīmeklisLaminin G domain-like (LG) modules of approximately 180-200 residues are found in a number of extracellular and receptor proteins and often are present in tandem arrays. … nim while loopTīmeklisLaminin. Laminin is a complex adhesion protein found in the ECM, especially within the basement membrane (Schwarzbauer, 1999 ). This protein plays an important role in … nuc flashing power light