Witryna1 lip 2024 · Orf3a, an accessory protein encoded by the genome of SARS-CoV-2, plays a significant role in viral infection and pathogenesis. In the present in-silico study, … Witryna16 lut 2024 · As ORF3a and E are potential ion channels for SARS-CoV/SARS-CoV-2, they have been proposed as candidates of drug targets (McClenaghan et al. 2024; …
SARS-CoV-2 ORF3a induces RETREG1/FAM134B-dependent …
Witryna5 lis 2024 · ORF3a increased intracellular calcium levels by 18-fold at 48 hours (p < 0.0001), as determined by the intracellular calcium indicator fluo-4. After 16 hours of … Witryna23 lis 2024 · ORF3a increased intracellular calcium levels by 18-fold at 48 hours (p < 0.0001), as determined by the intracellular calcium indicator fluo-4. After 16 hours of ORF3a expression, more than 60% of cells had externalized PS (p < 0.001) without increased cell death, as quantified by flow cytometry following annexin V binding. … ethiopian footballers
Endomembrane systems are reorganized by ORF3a and …
Witryna9 mar 2024 · Autophagy is a key mechanism for clearing pathogens, and many bacteria and viruses have evolved strategies for interfering with the formation or maturation of autophagosomes in host cells. Miao et al. systematically evaluated the effects of proteins encoded by SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, … Witryna16 gru 2024 · Miao et al. demonstrate that late endosome-localized ORF3a of the COVID-19 virus SARS-CoV-2 sequestrates the HOPS component VPS39. ORF3a … Witryna9 kwi 2024 · Severe acute respiratory syndrome coronavirus (SARS-CoV) is capable of inducing a storm of proinflammatory cytokines. In this study, we show that the SARS … fireplace store midland texas