Ptpmt1 hypoxia

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August undefined, 2024

WebNov 4, 2024 · Beneficial effects of miR-150 in vitro and in vivo were linked with PTPMT1-dependent biosynthesis of mitochondrial phospholipid cardiolipin and reduced expression … WebJan 3, 2013 · Here we report that depletion of PTPMT1, a PTEN-like mitochondrial phosphatase, in inducible or hematopoietic-cell-specific knockout mice resulted in hematopoietic failure due to changes in the cell cycle and a block in the differentiation of HSCs. Surprisingly, the HSC pool was increased by ∼40-fold in PTPMT1 knockout mice.

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WebMar 18, 2016 · In this study, we presented evidence that mitochondrial phosphatase Ptpmt1 is a hypoxia response molecule that regulates cell proliferation, survival and glucose metabolism in human erythroleukemia TF-1 cells. Exposure to hypoxia or DFO treatment results in upregulation of HIF1-α, HIF-2α and Ptpmt1. Only inhibition of HIF-2α by shRNA ... WebSpecifically, PTPMT1 knockout cells exhibited slower growth, lower viability, and less aggressive phenotypes both in vitro and in vivo – and hypoxia enhanced these changes. … stay for a night

PTPMT1 Inhibition Lowers Glucose through Succinate ... - Cell Reports

WebJun 8, 2011 · PTPMT1 was the first protein tyrosine phosphatase found localized to the mitochondria, but its biological function was unknown. Herein, we demonstrate that whole body deletion of Ptpmt1 in mice leads to embryonic lethality, suggesting an indispensable role for PTPMT1 during development. Ptpmt1 defic … WebMar 19, 2024 · PTPMT1 regulates cardiolipin synthesis and facilitates the assembly of the ETC complexes which alleviates ROS accumulation during hypoxia. Depletion or … WebNov 4, 2024 · PTPMT1 and cardiolipin levels were significantly reduced in Sugen/hypoxia mice, while miR-150 supplementation restored their expression to the level seen in healthy … stay for breakfast rate

Genome-wide CRISPR-Cas9 knockout library screening identified …

miR-150-PTPMT1-cardiolipin signaling in pulmonary arterial ... - Cell

WebA genome-wide CRISPR-Cas9 knockout screen has found that PTPMT1 is critical for hypoxic survival of liver cancer during cardiolipin synthesis, and that PTPMT1 silencing prevents … WebFeb 5, 2015 · Nath et al. use chemical screening in larval zebrafish to uncover pathways that lower glucose. The authors find that inhibition of the mitochondrial-specific phosphatase PTPMT1 leads to increased phosphorylation and activation of succinate dehydrogenase. These findings provide a possible mechanism by which PTPMT1 coordinates glucose … stay for christmas movieWebNov 1, 2024 · PTPMT1 and car diolipin levels w ere significantly reduced in Suge n/hypoxia mice, while 196 miR-150 supplementation restored their expression to the level seen in healthy mice ( Figure stay for a week hotel

"WebJul 5, 2011 · PTPMT1 (PTP localized to the Mitochondrion 1) was initially identified as a PTP that harbors a PTEN-like active site ().It is highly conserved throughout most major eukaryotic lineages and even in a few bacteria such as Pirellula (Fig. 1A and Fig. S1).As suggested by its name, PTPMT1 is localized in the mitochondrion, and is anchored at the … " - Ptpmt1 hypoxia

Ptpmt1 hypoxia

Mitochondrial phosphatase PTPMT1 is essential for cardiolipin ...

WebFeb 1, 2016 · Furthermore, atypical DUSP PTPMT1 is induced in response to hypoxia by hypoxia-inducible factor HIF-2α in erythroid leukemia cells, and its inhibition induces … WebHypoxia provokes metabolism misbalance, mitochondrial dysfunction and oxidative stress in both human and animal cells. However, the mechanisms which hypoxia causes mitochondrial dysfunction and energy metabolism misbalance still remain unclear. In …

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WebCM-H 2 DCFDA staining showed that ROS accumulated more dramatically in PTPMT1 KO cells under hypoxia than in normoxia ( Figures 2E and S1H). MitoPY1 is a small-molecule fluorescent probe that ... WebJan 26, 2024 · PTPMT1 KO cells under hypoxia than in normoxia (Figures 2 E. and S1 H). MitoPY1 is a small-molecule ﬂuorescent probe that. selectively targets a speciﬁc type of ROS, hydrogen peroxide (H. 2. O. 2

WebJan 26, 2024 · Bao et al. use CRISPR library screening to identify PTPMT1, an important gene for hypoxic survival of HCC cells. PTPMT1 synthesizes cardiolipin, a crucial … WebMar 19, 2024 · PTPMT1 regulates cardiolipin synthesis and facilitates the assembly of the ETC complexes which alleviates ROS accumulation during hypoxia. Depletion or pharmacological inhibition of PTPMT1 decreases tumor growth, disrupts the mitochondrial membrane and ETC formation, and reduced metastasis in different cancers [ 184 ].

WebMar 25, 2024 · PTPMT1 mediates homeostatic effects of miR-150 . Transfection of HPAECs with miR-150 markedly attenuated endothelial cell apoptosis, hypoxia-induced cell proliferation and hypoxia- and TNF-α-induced NFκB activation (Figure 4A-E). In contrast, inhibition of miR-150 markedly augmented endothelial damage and WebA genome-wide CRISPR-Cas9 knockout screen has found that PTPMT1 is critical for hypoxic survival of liver cancer during cardiolipin synthesis, and that PTPMT1 silencing prevents cardiolipin maturation, which in turn leads to ROS accumulation during hypoxia. PTPMT1 exhibited a high sensitivity to the PTPMT1 inhibitor alexidine dihydrochloride ...

WebJan 26, 2024 · PTPMT1 KO cells under hypoxia than in normoxia (Figures 2 E. and S1 H). MitoPY1 is a small-molecule ﬂuorescent probe that. selectively targets a speciﬁc type of … stay for freeWebJun 8, 2011 · Cardiolipin, a phospholipid component of the inner mitochondrial membrane, is required for mitochondrial metabolism. In this issue, Zhang et al. (2011) highlight a critical role for PTPMT1, a mitochondrial phosphatase, in cardiolipin biogenesis and possibly in cardiolipin deficiency diseases. Their findings also unveil a yet uncharacterized pathway … stay for dancingWebOct 1, 2015 · In this study, we presented evidence that mitochondrial phosphatase Ptpmt1 is a hypoxia response molecule that regulates cell proliferation, survival and glucose … stay for days slWebOct 1, 2015 · In this study, we presented evidence that mitochondrial phosphatase Ptpmt1 is a hypoxia response molecule that regulates cell proliferation, survival and glucose metabolism in human erythroleukemia TF-1 cells. Exposure to hypoxia or DFO treatment results in upregulation of HIF1-α, HIF-2α and Ptpmt1. Only inhibition of HIF-2α by shRNA ... stay for long refundWebFeb 10, 2015 · Lysates from ptpmt1 +/ ... SDH activity, supercomplex distribution in the mitochondria, and metabolic adaptation of mitochondria to starvation or hypoxia/reoxygenation (Acín-Pérez et al., 2014). Therefore, in addition to increasing glucose uptake by stimulating insulin secretion, PTPMT1 inhibition may increase the rate of … stay for golfWebNov 4, 2024 · PTPMT1 and cardiolipin levels were significantly reduced in Sugen/hypoxia mice, while miR-150 supplementation restored their expression to the level seen in healthy mice (Figures 6A–6C). Overexpression of PTPMT1 and miR-150 significantly elevated cardiolipin levels in cultured endothelial cells (p < 0.01 and p < 0.05, respectively) ( Figure … stay for free pubsWebMar 18, 2016 · In this study, we presented evidence that mitochondrial phosphatase Ptpmt1 is a hypoxia response molecule that regulates cell proliferation, survival and glucose … stay for long scam